Animal Experiments: A View from Muscular Dystrophy Research
نویسندگان
چکیده
منابع مشابه
Mammalian animal models for Duchenne muscular dystrophy.
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease that affects boys and leads to early death. In the quest for new treatments that improve the quality of life and in the search for a possible definitive cure, the use of animal models plays undoubtedly an important role. Therefore, a number of different mammalian models for DMD have been described. Much knowledge on the molecula...
متن کاملA brief history of muscular dystrophy research: a personal perspective.
The field of myology has undergone remarkable changes. From the period of early clinical descriptions and clinical classifications, new knowledge of these disorders has come from the developments of histopathology, enzyme histochemistry and later, immunocytochemistry and electron microscopy. These techniques have enhanced the understanding of the pathophysiology of myopathies at the cellular le...
متن کاملSerum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy
BACKGROUND To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity. METHODS Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy. RESULTS Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation a...
متن کاملGene therapy in large animal models of muscular dystrophy.
The muscular dystrophies are a group of genetically and phenotypically heterogeneously inherited diseases characterized by progressive muscle wasting, which can lead to premature death in severe forms such as Duchenne muscular dystrophy (DMD). In many cases they are caused by the absence of proteins that are critical components of the dystrophin-glycoprotein complex, which links the cytoskeleto...
متن کاملResearch Approaches towards a Cure for Duchenne Muscular Dystrophy
This report has been written for families who have one or more boys with Duchenne muscular dystrophy. It explains some basic scientific facts and shows the now numerous approaches with which research is trying to find a scientifically justified and thus effective therapy of Duchenne muscular dystrophy. Because scientists in more than one hundred laboratories in many countries of the world are w...
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ژورنال
عنوان ژورنال: TRENDS IN THE SCIENCES
سال: 2002
ISSN: 1884-7080,1342-3363
DOI: 10.5363/tits.7.9_22